2nd Edition of International Obesity and Metabolism Conference 2026

Speakers - IOMC2026

Jenny Gunton, 2nd Edition of the International Obesity and Metabolism Conference, Singapore

Jenny Gunton

Jenny Gunton

  • Designation: Westmead Institute for Medical Research
  • Country: Australia
  • Title: Ketogenic diets and supplements and obesity

Abstract

A ketogenic diet (KD) is a low-carbohydrate, high-fat dietary approach. Beyond treating neurologic disorders, KD has attracted significant media attention for its potential to improve obesity and diabetes. The diet induces a metabolic shift from glucose toward fatty acid oxidation and ketone body production. This shift leads to ketosis, which may reduce hunger, cause weight loss, and improve glycaemic control and insulin sensitivity.

In particular, the positive effects of KD lower insulin demand and may thereby improve β-cell function. However, the long-term efficacy, safety, and sustainability of KD, especially for diabetes, remain debated.

This talk will review the effects of ketogenesis and ketosis and the potential mechanisms underlying them, drawing on preclinical and clinical studies. It will highlight challenges and future directions for optimizing KD-based therapies.